Hardy-Weinberg Equilibrium for 2 Alleles Formula - Health High Risks

Formula:

pfreq = (CH + (0.5 * H)) / (CH + H + RH)
qfreq = (RH + (0.5 * H)) / (CH + H + RH)
ECH = pfreq * pfreq * (CH + H + RH)
EH = 2 * pfreq * qfreq * (CH + H + RH)
ERH = qfreq * qfreq * (CH + H + RH)
chi1 = ((CH - ECH) * (CH - ECH)) / ECH
chi2 = ((H - EH) * (H - EH)) / EH
chi3 = ((RH - ERH) * (RH - ERH)) / ERH
chi2 = chi1 + chi2 + chi3


Where,

CH = Common Homozygotes
H = Heterozygotes
RH = Rare Homozygotes
ECH = Expected Common Homozygotes
EH = Expected Heterozygotes
ERH = Expected Rare Homozygotes
pfreq = p Allele Frequency
pfreq = q Allele Frequency

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